Recent health crises, especially the COVID-19 pandemic, have highlighted the need to review the principles of neighborhood design with an emphasis on promoting health, resilience, and urban sustainability. Despite the proliferation of related studies, a coherent framework for integrating health, resilience, and physical quality dimensions into neighborhood design has not yet been presented. Therefore, the present study aimed to explain the design pattern of sustainable neighborhood units in the face of health crises. This research was conducted with an applied purpose and a qualitative approach based on content analysis. Data were collected through semi-structured interviews with residents and experts in the fields of architecture, urban development, and urban planning and continued until theoretical saturation was achieved. Data analysis was conducted based on Brown and Clark's six-step method and using MAXQDA software. The findings showed that the sustainable neighborhood design model is based on five main themes, including physical health, mental health, social health, neighborhood resilience, and design strategies, which were extracted from a set of sub-themes and initial codes. The results indicate that improving the quality of the indoor environment, developing open and semi-open spaces, the quality of social capital, increasing access to neighborhood services, physical flexibility, and pedestrianization are the most important strategies for improving the resilience of neighborhood units against health crises. The innovation of the research lies in providing an analytical framework for systematically linking stakeholder experiences, extracted themes, and health-oriented design strategies towards realizing a sustainable city.